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Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort
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- Mendes, Augusto J. (författare)
- University of Geneva,Geneva University Hospital
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- Ribaldi, Federica (författare)
- Geneva University Hospital,University of Geneva
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- Lathuiliere, Aurelien (författare)
- University of Geneva,Geneva University Hospital
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- Ashton, Nicholas J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,King's College London,Stavanger University Hospital,Sahlgrenska Academy
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- Janelidze, Shorena (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Wisconsin-Madison,University College London,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Scheffler, Max (författare)
- Geneva University Hospital
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- Assal, Frederic (författare)
- Geneva University Hospital
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- Garibotto, Valentina (författare)
- Geneva University Hospital,University of Geneva Medical School
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Pitié-Salpêtrière University Hospital,Sahlgrenska Academy,Sahlgrenska University Hospital,University of Science and Technology of China
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Frisoni, Giovanni B. (författare)
- Geneva University Hospital,University of Geneva
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(creator_code:org_t)
- 2024
- Engelska.
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Ingår i: JOURNAL OF NEUROLOGY. - 0340-5354 .- 1432-1459. ; 271:4, s. 1707-1716
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background and objective Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer's disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort.Methods The study included 114 participants (CU = 33; MCI = 67; Dementia = 14). The p-tau variants were correlated versus continuous measures of amyloid (A) and tau (T)-PET. The p-tau phospho-epitopes were assessed through: (i) effect sizes (delta) between diagnostic and A +/- and T +/- groups; (ii) receiver operating characteristic (ROC) analyses in A-PET and T-PET.Results The correlations between both plasma and CSF p-tau217 with A-PET and T-PET (r range 0.64-0.83) were stronger than those of p-tau181 (r range 0.44-0.79) and p-tau231 (r range 0.46-0.76). Plasma p-tau217 showed significantly higher diagnostic accuracy than p-tau181 and p-tau231 in (i) differences between diagnostic and biomarker groups (delta(range): p-tau217 = 0.55-0.96; p-tau181 = 0.51-0.67; p-tau231 = 0.53-0.71); (ii) ROC curves to identify A-PET and T-PET positivity (AUC(average): p-tau217 = 0.96; p-tau181 = 0.76; p-tau231 = 0.79). On the other hand, CSF p-tau217 (AUC(average) = 0.95) did not reveal significant differences in A-PET and T-PET AUC than p-tau181 (AUC(average) = 0.88) and p-tau231 (AUC(average) = 0.89).Discussion Plasma p-tau217 demonstrated better performance in the identification of AD pathology and clinical phenotypes in comparison with other variants of p-tau in a memory clinic cohort. Furthermore, p-tau217 had comparable performance in plasma and CSF. Our findings suggest the potential of plasma p-tau217 in the diagnosis and screening for AD, which could allow for a decreased use of invasive biomarkers in the future.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Plasma
- CSF
- p-tau
- Alzheimer's disease
- Amyloid
- Tau
- Alzheimer’s disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- Av författaren/redakt...
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Mendes, Augusto ...
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Ribaldi, Federic ...
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Lathuiliere, Aur ...
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Ashton, Nicholas ...
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Janelidze, Shore ...
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Zetterberg, Henr ...
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visa fler...
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Scheffler, Max
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Assal, Frederic
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Garibotto, Valen ...
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Blennow, Kaj, 19 ...
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Hansson, Oskar
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Frisoni, Giovann ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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JOURNAL OF NEURO ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet