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Association of regi...
Association of region-specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's disease
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Vontell, Regina T. (author)
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Gober, Ryan (author)
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Dallmeier, Julian (author)
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Brzostowicki, Daniel (author)
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Barreda, Ayled (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Kvartsberg, Hlin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Gultekin, Sakir Humayun (author)
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de Rivero Vaccari, Juan Pablo (author)
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Bramlett, Helen M. (author)
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Dietrich, W. Dalton (author)
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Keane, Robert W. (author)
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Davis, David A. (author)
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Rundek, Tatjana (author)
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Sun, Xiaoyan (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS. - 2352-8737. ; 10:1
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Abstract
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- INTRODUCTION: Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology.METHODS: We investigated the protein expression, morphological differences of Ng, and correlated Ng to hyperphosphorylated tau in the post mortem brains of 17 AD cases and 17 age- and sex-matched controls. In addition, we correlated the Ng expression with two different epitopes of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).RESULTS: We show a reduction of Ng immunopositive neurons and morphological differences in AD compared to controls. Ng immunostaining was negatively correlated with neurofibrillary tangles, humanized anti-ASC (IC100) positive neurons and anti-ASC positive microglia, in AD.DISCUSSION: The finding of a negative correlation between Ng and ASC speck protein expression in post mortem brains of AD suggests that the activation of inflammasome/ASC speck pathway may play an important role in synaptic degeneration in AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- axon
- inflammasome
- microglia
- neurogranin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vontell, Regina ...
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Gober, Ryan
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Dallmeier, Julia ...
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Brzostowicki, Da ...
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Barreda, Ayled
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Blennow, Kaj, 19 ...
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show more...
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Zetterberg, Henr ...
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Kvartsberg, Hlin ...
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Gultekin, Sakir ...
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de Rivero Vaccar ...
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Bramlett, Helen ...
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Dietrich, W. Dal ...
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Keane, Robert W.
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Davis, David A.
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Rundek, Tatjana
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Sun, Xiaoyan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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ALZHEIMERS & DEM ...
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University of Gothenburg