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A Multiplexed Urina...
A Multiplexed Urinary Biomarker Panel Has Potential for Alzheimer's Disease Diagnosis Using Targeted Proteomics and Machine Learning
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Hallqvist, Jenny (författare)
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Pinto, Rui C. (författare)
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Heywood, Wendy E. (författare)
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Cordey, Jonjo (författare)
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Foulkes, Alexander J. M. (författare)
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Slattery, Catherine F. (författare)
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Leckey, Claire A. (författare)
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Murphy, Eimear C. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, Jonathan M. (författare)
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Mills, Kevin (författare)
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Paterson, Ross W. (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - 1661-6596 .- 1422-0067. ; 24:18
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- As disease-modifying therapies are now available for Alzheimer's disease (AD), accessible, accurate and affordable biomarkers to support diagnosis are urgently needed. We sought to develop a mass spectrometry-based urine test as a high-throughput screening tool for diagnosing AD. We collected urine from a discovery cohort (n = 11) of well-characterised individuals with AD (n = 6) and their asymptomatic, CSF biomarker-negative study partners (n = 5) and used untargeted proteomics for biomarker discovery. Protein biomarkers identified were taken forward to develop a high-throughput, multiplexed and targeted proteomic assay which was tested on an independent cohort (n = 21). The panel of proteins identified are known to be involved in AD pathogenesis. In comparing AD and controls, a panel of proteins including MIEN1, TNFB, VCAM1, REG1B and ABCA7 had a classification accuracy of 86%. These proteins have been previously implicated in AD pathogenesis. This suggests that urine-targeted mass spectrometry has potential utility as a diagnostic screening tool in AD.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Alzheimer's
- urine
- machine learning
- biomarkers
- proteomics
- mass spectrometry
- diagnosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hallqvist, Jenny
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Pinto, Rui C.
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Heywood, Wendy E ...
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Cordey, Jonjo
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Foulkes, Alexand ...
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Slattery, Cather ...
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visa fler...
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Leckey, Claire A ...
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Murphy, Eimear C ...
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Zetterberg, Henr ...
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Schott, Jonathan ...
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Mills, Kevin
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Paterson, Ross W ...
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visa färre...
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- NATURVETENSKAP
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Göteborgs universitet