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Plasma biomarkers o...
Plasma biomarkers of Alzheimer's disease and related dementias in American Indians: The Strong Heart Study
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Suchy-Dicey, Astrid M. (author)
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Longstreth, W. T. (author)
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Rhoads, Kristoffer (author)
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Umans, Jason (author)
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Buchwald, Dedra (author)
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Grabowski, Thomas (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Reiman, Eric (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Alzheimer's and Dementia. - 1552-5260 .- 1552-5279.
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- INTRODUCTION: Identification of Alzheimer's disease (AD) needs inexpensive, noninvasive biomarkers, with validation in all populations. METHODS: We collected plasma markers in older American Indian individuals: phosphorylated-tau181 (pTau181); amyloid-beta (Aβ) 40,42; glial fibrillary acidic protein (GFAP); and neurofilament light chain (NfL). Plasma markers were analyzed for discriminant properties with cognitive status and etiology using receiver operating characteristic (ROC) analysis. RESULTS: PTau181, GFAP, NfL plasma values were significantly associated with cognition, but Aβ were not. Discriminant performance was moderate for individual markers, with pTau181, GFAP, NfL performing best, but an empirically selected panel of markers (age, sex, education, pTau181, GFAP, NfL, Aβ4240 ratio) had excellent discriminant performance (AUC>0.8). DISCUSSION: In American Indian individuals, pTau181 and Aβ values suggested more common pathology than in majority populations. Aβ was less informative than in other populations; however, all four markers were needed for a best-performing dementia diagnostic model. These data validate utility of AD plasma markers, while suggesting population-specific diagnostic characteristics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- ATN biomarkers
- cognition
- imaging
- memory
- plasma markers
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Suchy-Dicey, Ast ...
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Longstreth, W. T ...
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Rhoads, Kristoff ...
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Umans, Jason
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Buchwald, Dedra
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Grabowski, Thoma ...
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show more...
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Blennow, Kaj, 19 ...
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Reiman, Eric
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Zetterberg, Henr ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg