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S100 in mild trauma...
S100 in mild traumatic brain injury
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- Nygren De Boussard, Catharina (författare)
- Karolinska Institutet
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- Fredman, Pam, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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Lundin, Anders (författare)
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- Andersson, Kerstin (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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- Edman, Gunnar (författare)
- Karolinska Institutet
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- Borg, Jörgen (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Rehabiliteringsmedicin
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(creator_code:org_t)
- 2009-07-03
- 2004
- Engelska.
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Ingår i: Brain Injury. - : Informa UK Limited. - 0269-9052 .- 1362-301X. ; 18:7, s. 671-83
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- PRIMARY OBJECTIVES: To examine the diagnostic value of S100 in mild traumatic brain injury (MTBI). RESEARCH DESIGN: Prospective cohort study. METHODS AND PROCEDURES: S100B, S100A1B and S100BB concentrations were examined in sera from patients with MTBI with an arrival Glasgow Coma Scale score of 15 or 14, patients with orthopaedic injuries and non-injured subjects. MAIN OUTCOME AND RESULTS: Mean values and proportions of subjects above cut-off limits for S100B and S100A1B were significantly higher in each trauma group than in non-injured controls, but only for S100A1B when patients with MTBI were compared with controls with orthopaedic injuries. Using a 97.5 percentile cut-off limit, the sensitivity of S100A1B for MTBI vs orthopaedic injury was 61% (95% confidence interval (CI) 49-73%), specificity 77% (95% CI 62-93%). The area under the ROC curve did not approach 0.9 for any cut off limit. CONCLUSIONS: Diagnostic validity of S100 in acute MTBI was not demonstrated. S100A1B has merits for long-term prognostic studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Aged
- Biological Markers/blood
- Bone and Bones/injuries
- Brain Injuries/*blood
- Female
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- S100 Proteins/*blood
- Severity of Illness Index
- Time Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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