Search: id:"swepub:oai:gup.ub.gu.se/43723" >
Normal or increased...
Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption.
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Bajor, Antal, 1962 (author)
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Kilander, Anders, 1945 (author)
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- Fae, Anita, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Galman, Cecilia (author)
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- Jonsson, Olof, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Öhman, Lena, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Biomedicine, Department of Microbiology and Immunology,Institute of Medicine, Department of Internal Medicine
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Rudling, Mats (author)
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Sjövall, Henrik, 1954 (author)
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Stotzer, Per-Ove, 1958 (author)
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Ung, Kjell-Arne, 1951 (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Eur J Gastroenterol Hepatol. - 0954-691X. ; 18:4, s. 397-403
- Related links:
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https://gup.ub.gu.se...
Abstract
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- Introduction: Bile acid malabsorption as reflected by an abnormal 75Se-labelled homocholic acid-taurine (75SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear. Objectives: Primarily, to determine whether there is a reduced active bile acid uptake in the terminal ileum in patients with bile acid malabsorption. Secondarily, to study the linkage between bile acid malabsorption and hepatic bile acid synthesis. Methods: Ileal biopsies were taken from patients with diarrhoea and from controls with normal bowel habits. Maximal active bile acid uptake was assessed in ileal biopsies using a previously validated technique based on uptake of 14C-labelled taurocholate. To monitor the hepatic synthesis, 7[alpha]-hydroxy-4-cholesten-3-one, a bile acid precursor, was assayed in blood. The 75SeHCAT-retention test was used to diagnose bile acid malabsorption. Results: The taurocholate uptake in specimens from diarrhoea patients was higher compared with the controls [median, 7.7 (n=53) vs 6.1 [mu]mol/g per min (n=17)] (P<0.01) but no difference was seen between those with bile acid malabsorption (n=18) versus diarrhoea with a normal 75SeHCAT test (n=23). The 75SeHCAT values and 7[alpha]-hydroxy-4-cholesten-3-one were inversely correlated. Conclusions: The data do not support bile acid malabsorption being due to a reduced active bile acid uptake capacity in the terminal ileum. (C) 2006 Lippincott Williams & Wilkins, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bajor, Antal, 19 ...
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Kilander, Anders ...
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Fae, Anita, 1949
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Galman, Cecilia
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Jonsson, Olof, 1 ...
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Öhman, Lena, 196 ...
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show more...
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Rudling, Mats
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Sjövall, Henrik, ...
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Stotzer, Per-Ove ...
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Ung, Kjell-Arne, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Eur J Gastroente ...
- By the university
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University of Gothenburg