No effect of a type I collagen gel coating in uncemented implant fixation

• Uncemented joint replacement with a variety of substrate materials, structures, and coatings are commonplace in arthroplasty. Even with specialized surgical preparation of bone, intimate contact between the implant and host bone may not always be achieved. This study evaluated the in vivo effect of fibrillar atelopeptide and PEG crosslinked collagens coatings placed directly into porous sintered bead structures on bone ingrowth using a skeletally mature bicortical, bilateral ovine tibia model. Bone ingrowth into the implants increased with time, although differences were not significant. At 4 weeks woven bone was present within the pores that remodeled with time. Significantly lower levels of ingrowth were observed in the intramedullary region of the implants when compared with the cortical region. Implant metal type did not affect ingrowth in both regions analyzed. Both fibrillar and crosslinked forms of dermal type I collagen did not significantly alter bone ingrowth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

Alloys

Animals

Biocompatible Materials/*chemistry

Bone Cements/chemistry

Bone Substitutes/*chemistry

Bone and Bones/metabolism/pathology

Collagen/*chemistry

Collagen Type I/*chemistry

Cross-Linking Reagents/pharmacology

Gels/*chemistry

Male

Materials Testing

Microscopy

Electron

Scanning

Osseointegration

Polyethylene Glycols/*chemistry

Prostheses and Implants

Prosthesis Design

Sheep

Skin/metabolism

Stress

Mechanical

Tensile Strength

Tibia/pathology

Time Factors

Titanium/chemistry

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