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CD25-expressing B-l...
CD25-expressing B-lymphocytes in rheumatic diseases
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- Amu, Sylvie, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Stromberg, K. (författare)
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- Bokarewa, Maria, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Tarkowski, Andrej, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Brisslert, Mikael, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Scand J Immunol. - : Wiley. - 0300-9475. ; 65:2, s. 182-91
- Relaterad länk:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- B cells play an important role in the development of autoimmune diseases due to their production of autoantibodies, antigen-presenting capacity and production of pro-inflammatory cytokines. The purpose of the present study was to analyse B cells from rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients, with respect to their expression of the IL-2 receptor (IL-2R) subunit CD25. Using flow cytometry, we found that CD25(+) B cells from RA patients expressed significantly higher frequencies of CD122 and CD132 than CD25(+) B cells from control subjects, indicating a fully functional IL-2R. These CD25(+) B cells also expressed higher frequencies of the co-stimulatory molecule CD80, whereas IgM and IgA expression was decreased compared with CD25(+) B cells from healthy controls. In addition B cells from SLE patients co-expressed CD25 together with CD80, CD122, and CD132, but to a lower degree IgD and IgM, when compared with healthy controls. Taken together, our results indicate that CD25(+) B cells from RA and SLE patients are in a highly activated state, display a more mature phenotype and suggest that this B cell subset may be involved in the pathogenesis of RA and SLE.
Nyckelord
- Adult
- Aged
- Arthritis
- Rheumatoid/*immunology
- B-Lymphocytes/*immunology
- Female
- Humans
- Immunoglobulin A/immunology
- Immunoglobulin M/immunology
- Interleukin Receptor Common gamma Subunit/analysis
- Interleukin-2 Receptor alpha Subunit/*analysis
- Interleukin-2 Receptor beta Subunit/analysis
- Lupus Erythematosus
- Systemic/*immunology
- Lymphocyte Activation
- Male
- Middle Aged
- Phenotype
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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