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Monitoring of the i...
Monitoring of the intestinal mucosal perfusion using laser Doppler flowmetry after multivisceral transplantation
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- Oltean, Mihai, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Åneman, Anders, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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Dindelegan, G. (författare)
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visa fler...
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Molne, J. (författare)
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- Olausson, Michael, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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Herlenius, Gustaf, 1961 (författare)
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Transplantation proceedings. - 0041-1345. ; 37:8, s. 3323-4
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: Graft endothelium constitutes a prime target during acute rejection. Infiltration of T cells, monocytes, and enhanced endothelial-leukocyte interactions result in microvascular impairment and altered perfusion. MATERIALS AND METHODS: We measured mucosal blood flow using a laser Doppler flowmeter in three patients undergoing multivisceral transplantation. Thirty-seven measurements were performed through the ileostomy over the first 4 weeks posttransplantation. Most measurements were performed within a 24-hour interval from endoscopy and biopsy. RESULTS: Mucosal perfusion increased throughout the first postoperative week and eventually stabilized around levels specific for each patient. Mucosal perfusion remained stable during graft pancreatitis, but decreased 35% to 55% from baseline (the average value of the previous measurements) during acute rejection and sepsis. During the first week posttransplantation there was a gradual increase in mucosal perfusion, which might reflect regeneration after reperfusion injury. Increased mucosal perfusion did not seem to correlate with rejection or other adverse clinical events. A sudden decrease in mucosal perfusion of 30% or more compared to the previous measurements was associated with septic episodes and/or rejection.
Nyckelord
- Adult
- Aged
- Female
- Graft Rejection
- Humans
- Ileostomy
- Intestinal Mucosa/*blood supply/*ultrasonography
- Intestines/*transplantation
- Laser-Doppler Flowmetry/methods
- Middle Aged
- Monitoring
- Physiologic
- Postoperative Period
- Regional Blood Flow
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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