Influence of age, hypertension, and diabetes on cardiac reserve in a rat model

• Background Assessment of cardiac reserve is used to disclose heart disease and to predict outcome in humans. Low-dose dobutamine stress echocardiography (DSE) was used to study the influence of age, hypertension, and diabetes on cardiac reserve in the rat model. Methods Low-dose DSE was performed in four groups: 10 young, 10 adult, and 10 diabetic Whistar Kyoto rats, and 10 spontaneously hypertensive rats. Results Cardiac reserve assessed by low-dose DSE was shown to decrease with age and was impaired both in rat models of hypertension and diabetes. Less information was provided by measuring cardiac function at rest. Conclusions Cardiac reserve in rats is similar to humans in that it decreases with age and is impaired both in severe heart disease and during progression of myocardial dysfunction. We have shown that low-dose DSE in rats is a feasible and reliable method that could be used to study the development of heart disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Age Factors

Animals

Diabetes Mellitus

echocardiography

Hypertension

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)