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Factors associated ...
Factors associated with development of stroke long-term after myocardial infarction: experiences from the LoWASA trial
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- Herlitz, Johan, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,[external]
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- Holm, Johan (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Peterson, M. (författare)
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Karlson, Björn W., 1953 (författare)
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- Haglid Evander, Maria, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Erhardt, Leif RW (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- Wiley, 2005
- 2005
- Engelska.
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Ingår i: J Intern Med. - : Wiley. - 0954-6820 .- 1365-2796. ; 257:2, s. 201-7
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. PATIENTS: Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. DESIGN: The study was performed according to the probe design, that is open treatment and blinded end-point evaluation. SETTING: The study was performed in 31 hospitals in Sweden. The mean follow-up time was 5.0 years with a range of 1.7-6.7 years. RESULTS: In all, 3300 patients were randomized in the trial, of which 194 (5.9%) developed stroke (4.2% nonhaemorrhagic, 0.5% haemorrhagic and 1.3% uncertain. The following factors appeared as independent predictors for an increased risk of stroke: age, hazard ratio and 95% confidence interval (1.07; 1.05-1.08), a history of diabetes mellitus (2.4; 1.8-3.4), a history of stroke (2.3; 1.5-3.5), a history of hypertension (2.0; 1.5-2.7) and a history of smoking (1.5;1.1-2.0). Most of these factors were also predictors of a nonhaemorrhagic stroke whereas no predictor of haemorrhagic stroke was found. CONCLUSION: Risk indicators for stroke long-term after AMI were increasing age, a history of either diabetes mellitus, stroke, hypertension or smoking.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Age Factors
- Aged
- Anti-Inflammatory Agents
- Non-Steroidal/therapeutic use
- Anticoagulants/therapeutic use
- Aspirin/therapeutic use
- Cerebrovascular Accident/*etiology/prevention & control
- Female
- Follow-Up Studies
- Humans
- Hypertension/complications
- Male
- Myocardial Infarction/*complications/drug therapy
- Proportional Hazards Models
- Regression Analysis
- Risk Factors
- Smoking/adverse effects
- Time Factors
- Warfarin/therapeutic use
- acute myocardial infarction
- stroke
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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