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Subchondral bone re...
Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats.
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- Vasara, Anna I (författare)
- Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland
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- Hyttinen, M M (författare)
- Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Lammi, Mikko, 1961- (författare)
- Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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Lammi, P E (författare)
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- Långsjö, T K (författare)
- Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Lindahl, Anders, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine,Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Göteborg University, Gothenburg, Sweden
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- Peterson, Lars, 1936 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics,Institution of Orthopaedics, Göteborg University, Gothenburg, Sweden
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- Kellomäki, M (författare)
- Institue for Biomaterials, Tampere University of Technology, Tampere, Finland
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- Konttinen, Y T (författare)
- Department of Medicine, Invärtes Medicine, Helsinki University Hospital, Helsinki, Finland; ORTON Research Institute, Invalid Foundation, Helsinki, Finland; Department of Anatomy, University of Helsinki, Finland
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- Helminen, H J (författare)
- Department of Medicine, Invärtes Medicine, Helsinki University Hospital and ORTON Research Institute, Invalid Foundation, Helsinki and Department of Anatomy, University of Helsinki, Finland
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- Kiviranta, I (författare)
- Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2004
- 2004
- Engelska.
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Ingår i: Calcified tissue international. - : Springer Science and Business Media LLC. - 0171-967X .- 1432-0827. ; 74:1, s. 107-14
- Relaterad länk:
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http://link.springer...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Repair of cartilage damage with autologous chondrocyte transplantation (ACT) has become popular in clinical use during the past few years. Although clinical results have mostly been successful, several unanswered questions remain regarding the biological mechanism of the repair process. The aim of this study was to develop a goat model for ACT. The repair was not successful due to the graft delamination, but we characterize the subchondral changes seen after the procedure. A chondral lesion was created in 14 goat knees, operated on 1 month later with ACT, and covered with periosteum or a bioabsorbable poly-L/D-lactide scaffold. After 3 months, only two of the five lesions repaired with ACT showed partly hyaline-like repair tissue, and all lesions (n = 4) with the scaffold failed. Even though the lesions did not extend through the calcified cartilage, the bone volume and collagen organization of bone structure were decreased when assessed by quantitative polarized light microscopy. There was a significant loss of bone matrix and distortion of the trabecular structure of subchondral bone, which extended several millimeters into the bone. The subchondral bone demonstrated strong hyaluronan staining in the bone marrow and cartilaginous areas with signs of endochondral ossification, suggesting structural remodeling of the bone. The goat model used here proved not to be an optimal model for ACT. The changes in subchondral bone may alter the biomechanical properties of the subchondral plate and thus the long-term survival of the repair tissue after ACT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Animals
- Arthroscopy
- veterinary
- Biocompatible Materials
- chemistry
- Bioprosthesis
- Biopsy
- Cartilage Diseases
- pathology
- surgery
- Cartilage
- Articular
- transplantation
- ultrastructure
- Cell Transplantation
- Cells
- Cultured
- Chondrocytes
- transplantation
- ultrastructure
- Disease Models
- Animal
- Female
- Femur
- pathology
- transplantation
- Goats
- Hexanoic Acids
- chemistry
- Immunohistochemistry
- Lactic Acid
- chemistry
- Lactones
- chemistry
- Male
- Microscopy
- Polarization
- Surgical Flaps
- Time Factors
- Transplantation
- Autologous
- Articular cartilage
- biokemi
- cell research
- Materials Science
- ortopedi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Vasara, Anna I
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Hyttinen, M M
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Lammi, Mikko, 19 ...
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Lammi, P E
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Långsjö, T K
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Lindahl, Anders, ...
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visa fler...
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Peterson, Lars, ...
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Kellomäki, M
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Konttinen, Y T
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Helminen, H J
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Kiviranta, I
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomaterialveten ...
- Artiklar i publikationen
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Calcified tissue ...
- Av lärosätet
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Göteborgs universitet
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