Sökning: id:"swepub:oai:gup.ub.gu.se/52347" >
Assessment of grade...
Assessment of graded intestinal hypoperfusion and reperfusion using continuous saline tonometry in a porcine model.
-
- Fröjse, R (författare)
- Umeå universitet,Kirurgi
-
- Lehtipalo, Stefan (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Winsö, Ola (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
visa fler...
-
- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Biber, Björn, 1944 (författare)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care,Anestesiologi och intensivvård
-
- Arnerlöv, Conny (författare)
- Umeå universitet,Kirurgi
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- Engelska.
-
Ingår i: Eur J Vasc Endovasc Surg. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 28:1, s. 79-88
- Relaterad länk:
-
http://www.ejves.com...
-
visa fler...
-
http://www.ncbi.nlm....
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To evaluate effects of graded intestinal hypoperfusion and reperfusion on intestinal metabolic parameters as assessed by a modified continuous saline tonometry technique. MATERIALS: Twelve barbiturate-anaesthetized female pigs. METHODS: Measurements were performed prior to and during three predefined levels of superior mesenteric mean arterial blood pressure (P(SMA) 70, 50 and 30 mmHg, respectively, each 80 min long), obtained by an adjustable clamp around the origin of the superior mesenteric artery, and during reperfusion. We continuously measured jejunal mucosal perfusion (laser Doppler flowmetry), jejunal tissue oxygen tension (PO(2TISSUE); microoximetry) and intramucosal PCO(2) (continuous saline tonometry) and calculated net intestinal lactate production, mesenteric oxygenation, PCO(2) gap (jejunal mucosal PCO(2)-arterial PCO(2)) and pHi. RESULTS: At P(SMA) 70 and 50 mmHg mesenteric oxygen uptake and net lactate production remained unaltered, in spite of decreased oxygen delivery. At these P(SMA) levels PCO(2) gap increased, while pHi and PO(2TISSUE) decreased. At P(SMA) 30 mmHg pronounced increases in PCO(2) gap and mesenteric net lactate production as well as marked decreases in PO(2TISSUE) and pHi were demonstrated. Data indicate absence of anaerobic conditions at an intestinal perfusion pressure (IPP)> or =41 mmHg, a pHi> or =7.22 or PCO(2) gap< or =15.8 mmHg. CONCLUSIONS: Continuous saline tonometry detected intestinal ischemia as induced by graded reductions in IPP. A threshold could be defined above which intestinal ischemia does not occur.
Nyckelord
- Animals
- Blood Pressure
- physiology
- Cardiac Output
- physiology
- Female
- Heart Rate
- physiology
- Intestines
- blood supply
- metabolism
- Manometry
- Mesenteric Artery
- Superior
- metabolism
- Models
- Animal
- Models
- Cardiovascular
- Oxygen Consumption
- physiology
- Regional Blood Flow
- physiology
- Reperfusion
- Severity of Illness Index
- Sodium Chloride
- pharmacology
- Swine
- Vascular Resistance
- physiology
- Animals
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas