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CSF biomarkers for ...
CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival
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- Wallin, Anders, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Andreasen, N. (författare)
- Karolinska Institutet
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- Minthon, Lennart (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Wallin, Åsa (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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(creator_code:org_t)
- S. Karger AG, 2006
- 2006
- Engelska.
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Ingår i: Dement Geriatr Cogn Disord. - : S. Karger AG. ; 21:3, s. 131-138
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Cerebrospinal fluid (CSF) samples from 21 patients with a clinical diagnosis of Alzheimer's disease (AD) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of beta-amyloid (Abeta42), total tau (T-tau) and phosphorylated tau (P-tau). A significant positive correlation between the level of P-tau and the number of symptoms according to the DSM-IV criteria (p = 0.041) and the NINCDS-ADRDA (p = 0.029) was observed (i.e. higher levels were found in cases with more symptoms). A significant positive correlation between T-tau, P-tau and ADAS-cog score was identified (i.e. higher levels were found with more severe cognitive dysfunction). Patients who died during the 5-year follow-up had significantly lower levels of Abeta42 (p = 0.011) than those who were still alive. Patients who had died in a 6-year follow-up had significantly lower levels of Abeta42 (p = 0.034) and higher levels of T-tau (p = 0.041) than patients still alive. CONCLUSION: CSF biomarkers do aid the clinical diagnosis of AD. Increased levels of P-tau and T-tau are possible markers for severity and abundance of symptoms in AD. Low levels of Abeta42 may indicate a higher risk of early death in AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Aged
- Aged
- 80 and over
- Alzheimer Disease/cerebrospinal fluid/*diagnosis/drug therapy/mortality
- Amyloid beta-Protein/*cerebrospinal fluid
- Apolipoproteins E/genetics
- Biological Markers/*cerebrospinal fluid
- Diagnostic and Statistical Manual of Mental Disorders
- Female
- Genotype
- Humans
- Male
- Mental Status Schedule
- Middle Aged
- Nerve Tissue Proteins/*cerebrospinal fluid
- Neuropsychological Tests
- Peptide Fragments/*cerebrospinal fluid
- Phosphorylation
- Prognosis
- Reference Values
- Retrospective Studies
- Risk
- Statistics
- Survival Analysis
- Tacrine/therapeutic use
- tau Proteins
- tau
- phosphorylated tau
- tacrine
- survival
- Apo E
- beta-amyloid
- Alzheimer's disease
- cerebrospinal fluid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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