IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.

• The interleukin-1 receptor-associated kinase-1 (IRAK-1) mediates signal transduction from Toll-like/IL-1/IL-18 receptors. Though a critical protective role against Staphylococcus aureus infection has been previously attributed to myeloid differentiation factor 88 (MyD88) and IRAK-4, both also involved in TLR/IL-1/IL-18 signaling, the role of IRAK-1 is unknown. IRAK-1-deficient (IRAK-1-/-) and wild-type mice were inoculated i.v. with 2 x 10(7) or 1 x 10(6) S. aureus per mouse to evaluate the role of IRAK-1 in S. aureus sepsis. Since IRAK-1 transduces IL-1R signals, IL-1R-/- mice were also included in experiments. IRAK-1-/- mice are susceptible to a high dose of S. aureus compared to wild-type controls. In contrast to the high mortality and extensive weight loss seen in IL-1R-deficient mice in response to 1 x 10(6) S. aureus, IRAK-1-/- mice are resistant to this low dose of S. aureus. Thus IRAK-1 plays an important role in the host response to staphylococcal sepsis.

Nyckelord

Animals

Bacteremia

Blood

microbiology

Body Weight

Colony Count

Microbial

Disease Susceptibility

Female

Immunity

Natural

Interleukin-1

blood

Interleukin-1 Receptor-Associated Kinases

Interleukin-18

blood

Interleukin-18 Receptor alpha Subunit

Kidney

microbiology

Male

Membrane Glycoproteins

metabolism

Mice

Mice

Inbred C57BL

Mice

Knockout

Protein Kinases

genetics

metabolism

Receptors

Cell Surface

metabolism

Receptors

Interleukin

metabolism

Receptors

Interleukin-1

genetics

metabolism

Receptors

Interleukin-18

Signal Transduction

Staphylococcal Infections

enzymology

immunology

Staphylococcus aureus

immunology

Survival Analysis

Toll-Like Receptors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)