Testicular lymphoma--a retrospective, population-based, clinical and immunohistochemical study.

• From a population-based registry, 35 patients with histologically verified testicular lymphomas were identified: diffuse large B-cell lymphomas (DLBCL) in 33 and peripheral T-cell lymphomas in two cases. Twenty-two patients had localized disease (Pe stage I and II). Twenty-eight patients received systemic chemotherapy, 17 of whom also received intrathecal prophylaxis, and 12 out of these 17 also received radiotherapy to the contralateral testis. In the Pe stage I/II group, 7 out of 21 patients in complete remission (CR) relapsed. In 5 of them the CNS was involved (isolated CNS relapse in three). Remarkably late relapses occurred (up to 127 months). Intrathecal prophylaxis seemed to reduce the frequency of relapses involving the CNS, but the relatively short follow-up (median 45 months, range 34-88, for censored patients) prevents firm conclusions regarding efficacy. The outcome for the stage IV patients was poor, with only 1 out of 11 patients in continuous CR. Immunohistochemical analysis of the DLBCL tumours revealed that 31% had the germinal centre B-cell-like phenotype. CD44 was expressed in all the tumours of stage IV patients but in less than half of the Pe stage I/II patients. A high intratumoural microvessel density was correlated with a high degree of Ki-67 positive tumour cells and an inferior overall survival.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult

Age Factors

Aged

Aged

80 and over

Antineoplastic Combined Chemotherapy Protocols

therapeutic use

Biopsy

Needle

Cause of Death

Follow-Up Studies

Humans

Immunohistochemistry

Lymphoma

Large-Cell

Diffuse

mortality

pathology

therapy

Male

Middle Aged

Neoplasm Staging

Probability

Proportional Hazards Models

Radiotherapy

High-Energy

methods

Registries

Retrospective Studies

Risk Assessment

Statistics

Nonparametric

Survival Analysis

Testicular Neoplasms

mortality

pathology

therapy

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)