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Neurokinin 1 recept...
Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection.
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- Svensson, Alexandra, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Kaim, Joanna, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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- Mallard, Carina, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Olsson, Annika (författare)
- Karolinska Institutet
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- Brodin, Ernst (författare)
- Karolinska Institutet
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- Hökfelt, Tomas (författare)
- Karolinska Institutet
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- Eriksson, Kristina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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(creator_code:org_t)
- The American Association of Immunologists, 2005
- 2005
- Engelska.
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Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 175:10, s. 6802-11
- Relaterad länk:
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http://www.jimmunol....
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- We show that genital infection with neurotropic HSV type 2 (HSV-2) induced a significant increase of the neuropeptide substance P (SP) within the genital tract of mice. SP was shown to weakly interfere with the HSV-2 replication. Furthermore, lack of SP signaling through the use of mice deficient in the SP receptor, neurokinin 1 receptor (NK1R), revealed an important role for SP in the innate defense against HSV-2. NK1R-deficient mice had significantly enhanced levels of HSV-2 in the genital tract and in the CNS following infection and a significantly accelerated disease progression, which was associated with an impaired NK cell activity locally in the vagina. Lack of NK1R signaling did, however, not impair the animals' ability to mount a protective immune response to HSV-2 following vaccination with an attenuated virus. Both NK1R+/+ and NK1R-/- mice developed strong HSV-2-specific Th1 T cell responses following vaccination. No genital viral replication was observed in either vaccinated NK1R-deficient or NK1R+/+ control animals following a genital HSV-2 challenge, and all of these animals survived without any symptoms of disease. In conclusion, the present results indicate that SP and NK1R signaling contributes to the innate resistance against HSV-2 infection in mice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Animals
- Central Nervous System
- pathology
- virology
- Female
- Herpes Genitalis
- immunology
- metabolism
- prevention & control
- virology
- Herpes Simplex Virus Vaccines
- pharmacology
- Herpesvirus 2
- Human
- drug effects
- immunology
- physiology
- Immunity
- Natural
- Killer Cells
- Natural
- immunology
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Receptors
- Neurokinin-1
- deficiency
- genetics
- immunology
- Signal Transduction
- Substance P
- metabolism
- pharmacology
- Vaccines
- Attenuated
- pharmacology
- Vagina
- immunology
- metabolism
- virology
- Virus Replication
- drug effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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