Lamivudine resistance of hepatitis B virus masked by coemergence of mutations in probe region of the COBAS AMPLICOR assay.

• The COBAS AMPLICOR hepatitis B virus assay targets a conserved region of the genome and is widely used to monitor treatment of hepatitis B in order to identify emerging resistance. However, the assay failed to recognize increasing viremia levels when YMDD mutations were paralleled by mutations in the segment targeted by the COBAS AMPLICOR probe.

Nyckelord

Antiviral Agents

pharmacology

Base Sequence

DNA Probes

DNA

Viral

chemistry

genetics

Drug Resistance

Viral

genetics

False Negative Reactions

Hepatitis B virus

drug effects

genetics

Hepatitis B

Chronic

drug therapy

virology

Humans

Lamivudine

pharmacology

Male

Middle Aged

Molecular Sequence Data

Mutation

Reagent Kits

Diagnostic

Sequence Analysis

DNA

Viral Load

Publikations- och innehållstyp

ref (ämneskategori)

for (ämneskategori)