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A polymorphism in t...
A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.
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- Melke, Jonas, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Westberg, Lars, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Nilsson, Staffan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Landén, Mikael, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för psykiatri,Institute of Clinical Neurosciences, Section of Psychiatry,University of Gothenburg
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- Söderström, Henrik, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för psykiatri,Institute of Clinical Neurosciences, Section of Psychiatry,University of Gothenburg
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- Baghaei, Fariba, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Rosmond, Roland, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Holm, Göran, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Björntorp, Per, 1931 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,University of Gothenburg
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Stockholm University
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- Adolfsson, Rolf (författare)
- Umeå universitet,Umeå University
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- Eriksson, Elias, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Anckarsäter, Henrik (författare)
- Lund University,Lunds universitet,Rättspsykiatri, Malmö,Forskargrupper vid Lunds universitet,Forensic Psychiatry, Malmö,Lund University Research Groups
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(creator_code:org_t)
- American Medical Association (AMA), 2003
- 2003
- Engelska.
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Ingår i: Archives of general psychiatry. - : American Medical Association (AMA). - 0003-990X. ; 60:10, s. 1017-23
- Relaterad länk:
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https://jamanetwork....
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http://dx.doi.org/10...
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http://www.ncbi.nlm.... (free)
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http://archpsyc.jama...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance. OBJECTIVE: To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women. DESIGN: Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated. RESULTS: A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P<.001). In the pooled sample, all harm avoidance subscales were found to be significantly associated with the C178T polymorphism: anticipatory worry (P =.001), fear of uncertainty (P<.001), shyness (P<.001), and fatigability and asthenia (P =.008). In addition, a significant association was found in sample 1 between the C178T polymorphism and the Karolinska Scales of Personality nonconformity factor (corrected P =.002), including the subscales of social desirability (P<.001), indirect aggression (P =.002), verbal aggression (P =.05), and irritability (P<.001). Participants homozygous for the less common T allele (<4%) differed from the remaining women by displaying lower ratings on harm avoidance and nonconformity. CONCLUSION: The C178T polymorphism in the HTR3A gene may affect the personality trait of harm avoidance in women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Adult
- Cohort Studies
- Female
- Genotype
- Humans
- Middle Aged
- Personality
- classification
- genetics
- Personality Assessment
- Personality Inventory
- Polymorphism
- Genetic
- genetics
- Receptors
- Serotonin
- 5-HT3
- genetics
- Serine Endopeptidases
- genetics
- Sweden
- Serine Endopeptidases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Melke, Jonas, 19 ...
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Westberg, Lars, ...
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Nilsson, Staffan ...
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Landén, Mikael, ...
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Söderström, Henr ...
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Baghaei, Fariba, ...
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Rosmond, Roland, ...
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Holm, Göran, 194 ...
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Björntorp, Per, ...
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Nilsson, Lars-Gö ...
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Adolfsson, Rolf
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Eriksson, Elias, ...
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Anckarsäter, Hen ...
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Göteborgs universitet
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Chalmers tekniska högskola
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Lunds universitet