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Cerebrospinal fluid...
Cerebrospinal fluid HIV-1 infection usually responds well to antiretroviral treatment.
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- Mellgren, Åsa, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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Antinori, Andrea (författare)
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Cinque, Paola (författare)
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Price, Richard W (författare)
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Eggers, Christian (författare)
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- Hagberg, Lars, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Antiviral therapy. - 1359-6535. ; 10:6, s. 701-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The primary objective of this retrospective study was to determine how many patients in routine practice who were treated with combination antiretroviral treatment reached HIV-1 RNA levels below 50-400 copies/ml in cerebrospinal fluid (CSF). Seventy-four antiretroviral-naive HIV-1-infected patients from five different centres in Germany, Italy, Sweden and the USA were included. Thirty-nine percent of the patients had a HIV-1-associated neurological disease and 53% of the patients had AIDS. HIV-1 RNA in CSF and plasma were quantified before and after approximately 3 months of treatment. At baseline, the median value of HIV-1 RNA in CSF was 4.12 log copies/ml (interquartile range (IQR): 3.28-4.85) and it decreased to < 1.70 log copies/ml (IQR: < 1.70-2.48; P < 0.001) after in median 3 months of treatment. Seventy-six percent of the patients had HIV-1 RNA levels below the limits of detection in CSF at follow-up, and 85% reached below 400 copies/ml. In plasma, 45% of the patients had levels of HIV-1 RNA below the limits of detection at follow-up and 80% reached below 400 copies/ml. The group of patients with a neurological disease had a significantly higher CSF viral load both at baseline and at follow-up compared with the neurologically asymptomatic patients. We conclude that the central nervous system (CNS) is usually not a 'sanctuary site', difficult to reach with combination antiretroviral treatment.
Nyckelord
- AIDS Dementia Complex
- cerebrospinal fluid
- drug therapy
- virology
- Adult
- Anti-HIV Agents
- therapeutic use
- Drug Therapy
- Combination
- Female
- HIV Infections
- cerebrospinal fluid
- drug therapy
- virology
- HIV-1
- drug effects
- Humans
- Male
- Middle Aged
- RNA
- Viral
- blood
- cerebrospinal fluid
- Retrospective Studies
- Reverse Transcriptase Inhibitors
- therapeutic use
- Treatment Outcome
- Viral Load
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Mellgren, Åsa, 1 ...
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Antinori, Andrea
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Cinque, Paola
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Price, Richard W
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Eggers, Christia ...
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Hagberg, Lars, 1 ...
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Gisslén, Magnus, ...
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Antiviral therap ...
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Göteborgs universitet