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Prospective randomi...
Prospective randomized study comparing ultrasound-guided thrombin injection to compression in the treatment of femoral pseudoaneurysms
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- Lönn, Lars, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology
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- Olmarker, Anne (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology
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- Geterud, Kjell (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology
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- Risberg, Bo, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: J Endovasc Ther. - 1526-6028. ; 11:5, s. 570-6
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Abstract
Subject headings
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- PURPOSE: To compare in a randomized prospective study the treatment of femoral pseudoaneurysms with ultrasound-guided thrombin injection versus ultrasound-guided compression. METHODS: Thirty consecutive patients (22 men; mean age 67+/-8 years, range 53-82) with iatrogenic femoral pseudoaneurysms were randomized to treatment with either ultrasound-guided compression (n=15) or injection of bovine thrombin (n=15). The primary outcome measure was thrombosis of the pseudoaneurysm within 24 hours. Secondary outcome measures were complications and hospitalization time (LOS). RESULTS: Thrombosis within 24 hours was achieved in 15 (100%) patients given thrombin versus 2 (13%) in the compression group (p<0.001). Of 13 pseudoaneurysms failing the initial compression treatment, 7 were retreated, 4 successfully. Thus, only 6 (40%) lesions were thrombosed within 48 hours after 1 or 2 compression sessions. The other 9 cases were successfully treated with thrombin injection. LOS was 2.8+/-1.5 days and 3.5+/-2.4 days in the thrombin and compression groups, respectively (p>0.05). No complications were noted in either group. CONCLUSIONS: Ultrasound-guided thrombin injection induces a fast, effective, and safe thrombosis of postcatheterization pseudoaneurysms. The technique is clearly superior to compression treatment and is recommended as the therapy of choice.
Keyword
- Aged
- Aged
- 80 and over
- Aneurysm
- False/*therapy/ultrasonography
- Female
- *Femoral Artery/ultrasonography
- *Hemostatic Techniques
- Hemostatics/*administration & dosage
- Humans
- Injections
- Intralesional
- Male
- Middle Aged
- Pressure
- Prospective Studies
- Thrombin/*administration & dosage
- Ultrasonography
- Doppler
- Color
Publication and Content Type
- ref (subject category)
- art (subject category)
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