Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD).

• We serendipitously identified a single nucleotide polymorphism (SNP), 8636C>A (rs1804197) in the 3'-untranslated region of the adenomatous polyposis coli (APC) gene to be associated with autism spectrum disorder (ASD). In order to gain further evidence for the association between the APC locus and ASD, we genotyped four additional adjacent common SNPs (rs2229992, rs42427, rs459552, and rs465899) in the coding regions within the APC gene in a set of Swedish ASDs and controls. One common haplotype TGAG was found to be associated with ASD after haplotype analysis using both Haploview v3.1.1 (P = 0.006) and COCAPHASE v2.403 (P = 0.030). This result is the first to suggest that the genomic locus at APC is associated with ASD, and that the APC gene itself is a good predisposing candidate to be evaluated in future studies due to its important role in neuronal development and function.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Adolescent

Adult

Autistic Disorder

Genetics

Case-Control Studies

Child

Child

Preschool

Female

Gene Frequency

Genes

APC

Genetic Linkage

Genotype

Humans

Male

Middle Aged

Polymorphism

Single Nucleotide

Retrospective Studies

autism spectrum disorder (ASD)

haplotype

SNP

association

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)