Pathological survivin expression links viral infections with pathogenesis of erosive rheumatoid arthritis.

• Rheumatoid arthritis (RA) is an inflammatory joint disease leading to cartilage and bone destruction. Insufficient apoptosis in the inflamed RA synovium along with accumulation of highly differentiated B- and T-lymphocytes as well as invasive growth of macrophages and fibroblasts is among the major mechanisms supporting joint destruction. We have recently shown that circulating survivin, an apoptosis inhibitor tightly bound to tumorigenesis, is an independent predictor of development and progression of joint destruction in RA. In this review we discuss the possible connectivity between viral infection, leading to interferon (IFN)-alpha production, survivin expression, and subsequent joint inflammation. The role of IFN-alpha and the involvement of IFN transcription factors and phosphoinositide-3-kinase signalling as essential modulators of arthritogenic process are discussed in the context of survivin.

Nyckelord

Animals

Arthritis

Rheumatoid

immunology

metabolism

pathology

virology

Humans

Microtubule-Associated Proteins

biosynthesis

blood

genetics

Neoplasm Proteins

biosynthesis

blood

genetics

Retroviridae

pathogenicity

Retroviridae Infections

immunology

metabolism

pathology

Tumor Virus Infections

immunology

metabolism

pathology

MEDICINE

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