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Influence of nonfat...
Influence of nonfatal hospitalization for heart failure on subsequent mortality in patients with chronic heart failure
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Solomon, S. D. (författare)
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Dobson, J. (författare)
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Pocock, S. (författare)
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visa fler...
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Skali, H. (författare)
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McMurray, J. J. (författare)
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Granger, C. B. (författare)
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Yusuf, S. (författare)
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- Swedberg, Karl, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
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Young, J. B. (författare)
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Michelson, E. L. (författare)
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Pfeffer, M. A. (författare)
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visa färre...
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Circulation. - 1524-4539. ; 116:13, s. 1482-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: Patients with chronic heart failure (HF) are at increased risk of both fatal and nonfatal major adverse cardiovascular events. We used data from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) trials to assess the influence of nonfatal hospitalizations for HF on subsequent mortality rates in a broad spectrum of HF patients. METHODS AND RESULTS: In the present study, 7599 patients with New York Heart Association class II to IV HF and reduced or preserved left ventricular ejection fraction were randomized to placebo or candesartan. We assessed the risk of death after discharge from a first hospitalization for HF using time-updated Cox proportional-hazards models on 7572 patients for whom discharge data were available. Of 7572 patients, 1455 (19%) had at least 1 HF hospitalization, and 586 of 1819 deaths occurred after discharge from an HF hospitalization. The mortality rate was increased after HF hospitalizations, even after adjustment for baseline predictors of death (hazard ratio, 3.15; 95% confidence interval, 2.83 to 3.50). Longer duration of HF hospitalization enhanced the risk of dying, as did repeat HF hospitalizations. Moreover, risk of death was highest within a month of discharge and then declined progressively over time, particularly for death resulting from HF progression and for sudden cardiac death. We observed a similar pattern of risk associated with all-cause hospitalization, although the magnitude was less than that with HF hospitalization. CONCLUSIONS: In patients with chronic HF, the risk of death is greatest in the early period after discharge after a hospitalization for HF and is directly related to the duration and frequency of HF hospitalizations. These findings suggest a role for increased surveillance in the early postdischarge period of greatest vulnerability after an HF admission.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aftercare
- Aged
- Aged
- 80 and over
- Angiotensin II Type 1 Receptor Blockers/therapeutic use
- Benzimidazoles/therapeutic use
- Death
- Sudden
- Cardiac/epidemiology
- Disease Progression
- Female
- Follow-Up Studies
- Heart Failure/drug therapy/*mortality
- Hospitalization/*statistics & numerical data
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Randomized Controlled Trials as Topic/statistics & numerical data
- Survival Analysis
- Tetrazoles/therapeutic use
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Solomon, S. D.
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Dobson, J.
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Pocock, S.
-
Skali, H.
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McMurray, J. J.
-
Granger, C. B.
-
visa fler...
-
Yusuf, S.
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Swedberg, Karl, ...
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Young, J. B.
-
Michelson, E. L.
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Pfeffer, M. A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Göteborgs universitet