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Reduced cortical bo...
Reduced cortical bone mass in mice with inactivation of interleukin-4 and interleukin-13.
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- Silfverswärd, Carl-Johan (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Ortopedi
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- Larsson, Sune (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Ortopedi
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Frost, Anders (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Nilsson, Olle (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. - : Wiley. - 0736-0266 .- 1554-527X. ; 25:6, s. 725-31
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aim of the present study was to study the in vivo role of IL-4 and IL-13 on bone metabolism. The skeletal phenotypes of male and female IL-13(-/-) (n = 7+7), IL-4(-/-)IL-13(-/-) (n = 7+7), and WT (n = 7+7) mice were compared. Analysis was made at 6 weeks of age (juvenile) by pQCT, and at 20 weeks of age (adult) by pQCT, biomechanical testing, and by S-IGF-1 and S-Osteocalcin measurements. The skeletal phenotype was affected only in adult male IL-4(-/-)IL-13(-/-) mice. These animals displayed a reduction in cortical bone mineral content (BMC) of both the tibia and the femur, as measured by mid-diaphyseal pQCT scans, compared with WT mice (tibia -8.2%; femur -8.5%; p < 0.01). This reduction in cortical BMC was due to a decreased cross-sectional area as a result of a reduced cortical thickness. The mechanical strength of the cortical bone, tested by three-point-bending at the mid-diaphyseal region of the femurs, demonstrated a significant reduction of displacement at failure (-11.4%), maximal load at failure (-10.6%), and total energy until failure (-29.4%). S-IGF-1 and S-Osteocalcin levels as well as trabecular bone mineral density (tvBMD) were unaffected in adult male IL-4(-/-)IL-13(-/-) mice. IL-4(-/-)IL-13(-/-) male mice show adult onset reduction of cortical bone mass and strength, indicating that the two anti-inflammatory Th(2) cytokines IL-4 and IL-13 are involved in the regulation of bone remodeling.
Nyckelord
- Animals
- Bone Density
- immunology
- Bone Remodeling
- immunology
- Bone Resorption
- immunology
- physiopathology
- radiography
- Female
- Femur
- immunology
- physiopathology
- radiography
- Insulin-Like Growth Factor I
- metabolism
- Interleukin-13
- genetics
- Interleukin-4
- genetics
- Male
- Mice
- Mice
- Inbred BALB C
- Mice
- Transgenic
- Osteocalcin
- blood
- Ovariectomy
- Phenotype
- Tibia
- immunology
- physiopathology
- radiography
- Tomography
- X-Ray Computed
- Weight-Bearing
- bone
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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