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Influence of oestro...
Influence of oestrogen receptor alpha and beta on the immune system in aged female mice.
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- Islander, Ulrika, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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Erlandsson, M C (författare)
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- Hasséus, Bengt, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för endodonti med oral diagnostik,Institute of Odontology, Department of Endodontology/Oral Diagnosis
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Jonsson, C A (författare)
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Gustafsson, J-A (författare)
- Karolinska Institutet
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- Dahlgren, Ulf, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Carlsten, Hans, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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(creator_code:org_t)
- Wiley, 2003
- 2003
- Engelska.
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Ingår i: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 110:1, s. 149-57
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Abstract
Ämnesord
Stäng
- Oestrogen has a dichotomous effect on the immune system. T and B lymphopoiesis in thymus and bone marrow is suppressed, whereas antibody production is stimulated by oestrogen. In this study the importance of the oestrogen receptors (ER) ER-alpha and ER-beta in the aged immune system was investigated in 18 months old-wild type (WT), ER-alpha (ERKO), ER-beta (BERKO) and double ER-alpha and ER-beta (DERKO) knock-out mice, and compared with 4 months old WT mice. Cell phenotypes in bone marrow, spleen and thymus, and the frequency of immunoglobulin (Ig) spot forming cells (SFC) were determined. We show here that the 17-beta-oestradiol (E2)-induced downregulation of B lymphopoietic cells in bone marrow of young ovariectomized mice can be mediated through both ER-alpha and ER-beta. However, only ER-alpha is required for the age-related increased frequency of immunoglobulin M (IgM) SFC in the bone marrow, as well as for the increased production of interleukin-10 (IL-10) from cultured splenocytes in aged mice. Furthermore, increased age in WT mice resulted in lower levels of both pro- and pre-B cells but increased frequency of IgM SFC in the bone marrow, as well as increased frequency of both IgM and IgA SFC in the spleen. Results from this study provide valuable information regarding the specific functions of ER-alpha and ER-beta in the aged immune system.
Nyckelord
- Aging
- immunology
- Animals
- B-Lymphocytes
- immunology
- Bone Marrow Cells
- immunology
- Cells
- Cultured
- Estradiol
- blood
- pharmacology
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Female
- Immunoglobulin A
- biosynthesis
- Immunoglobulin M
- biosynthesis
- Immunophenotyping
- Lymphopoiesis
- drug effects
- immunology
- Mice
- Mice
- Knockout
- Ovariectomy
- Receptors
- Estrogen
- immunology
- metabolism
- Spleen
- immunology
- T-Lymphocytes
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Islander, Ulrika ...
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Erlandsson, M C
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Hasséus, Bengt, ...
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Jonsson, C A
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Ohlsson, Claes, ...
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Gustafsson, J-A
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visa fler...
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Dahlgren, Ulf, 1 ...
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Carlsten, Hans, ...
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- Artiklar i publikationen
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Immunology
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet