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Expression and loca...
Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development.
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- Kindblom, Jenny, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Nilsson, O (författare)
- Karolinska Institutet
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Hurme, T (författare)
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Sävendahl, Lars (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: The Journal of endocrinology. - 0022-0795. ; 174:2
- Relaterad länk:
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Indian Hedgehog (Ihh) has been reported to control the rate of cartilage differentiation during skeletal morphogenesis in rodents through a negative feedback loop involving parathyroid hormone related protein (PTHrP). The role of Ihh and PTHrP in the regulation of human epiphyseal chondrocytes is unknown. The aim of the current study was to examine the expression and localization of Ihh and PTHrP in the human growth plate at various pubertal stages. Growth plate biopsies were obtained from patients subjected to epiphyseal surgery and the expression of Ihh and PTHrP was detected by immunohistochemistry. We show that Ihh and PTHrP are expressed mainly in early hypertrophic chondrocytes in the human growth plate. The levels of expression of Ihh and PTHrP are higher in early stages of puberty than later. Our results suggest that Ihh and PTHrP are present in the human growth plate and that Ihh and PTHrP may be involved in the regulation of pubertal growth in humans.
Nyckelord
- Adolescent
- Child
- Female
- Growth Plate
- chemistry
- Hedgehog Proteins
- Humans
- Image Processing
- Computer-Assisted
- Immunohistochemistry
- methods
- Male
- Parathyroid Hormone-Related Protein
- Proteins
- analysis
- Puberty
- metabolism
- Trans-Activators
- analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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