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Role of oestrogen r...
Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus.
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Erlandsson, M C (författare)
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Gustafsson, J A (författare)
- Karolinska Institutet
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- Carlsten, Hans, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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(creator_code:org_t)
- Wiley, 2001
- 2001
- Engelska.
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Ingår i: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 103:1, s. 17-25
- Relaterad länk:
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https://www.ncbi.nlm...
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Oestrogens affect the development and regulation of the immune system. To determine the role of oestrogen receptors alpha (ER-alpha) and beta (ER-beta) on the development of the immune system, male ER-alpha (ERKO) and ER-beta (BERKO) mice, as well as alphabeta-double knockout (DERKO) mice, were studied. Deletion of ER-alpha led to hypoplasia of both thymus and spleen. Interestingly, a higher frequency of immature double CD4+ CD8+ thymocytes was found in ER-alpha(-) mice compared with ER-alpha(+) mice. Female oophorectomized BERKO mice given oestradiol (E2) displayed a similar degree of thymic atrophy compared with the wild-type strain but showed only limited involution of thymus cortex and no alteration of thymic CD4/CD8 phenotype expression. Our data demonstrate that expression of ER-alpha, but not ER-beta, is mandatory in males for development of full-size thymus and spleen, whereas expression of ER-beta is required for E2-mediated thymic cortex atrophy and thymocyte phenotype shift in females. A potential background for the above findings may be down-regulated activity in the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in males lacking ER-alpha and suppressed sensitivity of females lacking ER-beta to E2-mediated suppression of IGF-1.
Nyckelord
- Animals
- Atrophy
- chemically induced
- CD4-Positive T-Lymphocytes
- physiology
- CD8-Positive T-Lymphocytes
- physiology
- Estradiol
- pharmacology
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Estrogens
- physiology
- Female
- Humans
- Insulin-Like Growth Factor I
- biosynthesis
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Receptors
- Estrogen
- genetics
- physiology
- Spleen
- growth & development
- pathology
- Thymus Gland
- growth & development
- immunology
- pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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