Effects of growth hormone and its secretagogues on bone.

• The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as well as in adult GH-deficient humans, but the effect of GH treatment on bone mass in healthy humans has so far not been impressive. Recently, a new class of GH secretagogues (GHSs) has been developed. In humans, GHS treatment affects biochemical markers of bone turnover and increases growth velocity in selected short children with or without GH deficiency. In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans.

Nyckelord

Adult

Age Factors

Animals

Bone Development

drug effects

Bone Remodeling

drug effects

Bone Resorption

physiopathology

Bone and Bones

anatomy & histology

drug effects

Ghrelin

Growth Hormone

deficiency

pharmacology

Growth Hormone-Releasing Hormone

pharmacology

Hormones

pharmacology

Humans

Indoles

pharmacology

Oligopeptides

pharmacology

Organ Size

Peptide Hormones

Peptides

pharmacology

Spiro Compounds

pharmacology

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