Unmyelinated tactile afferents have opposite effects on insular and somatosensory cortical processing.

• A previous functional magnetic resonance imaging (fMRI) study of an A-beta deafferented subject (GL) showed that stimulation of tactile C afferents (CT) activates insular cortex whereas no activation was seen in somatosensory cortices. Psychophysical studies suggested that CT afferents contribute to affective but not to discriminative aspects of tactile stimulation. We have now examined cortical processing following CT stimulation in a second similarly deafferented subject (IW), as well as revisited the data from GL. The results in IW showed similar activation of posterior insular cortex following CT stimulation as in GL and so strengthen the view that CT afferents underpin emotional aspects of touch. In addition, CT stimulation evoked significant fMRI deactivation in somatosensory cortex in both subjects supporting the notion that CT is not a system for discriminative touch.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Afferent Pathways

physiology

Brain Mapping

Cerebral Cortex

blood supply

physiology

Emotions

physiology

Female

Gyrus Cinguli

blood supply

physiology

Humans

Image Processing

Computer-Assisted

methods

Magnetic Resonance Imaging

methods

Male

Middle Aged

Nerve Fibers

Unmyelinated

physiology

Oxygen

blood

Physical Stimulation

methods

Psychophysics

Somatosensory Cortex

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)