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Hyperinsulinemic ra...
Hyperinsulinemic rats are normotensive but sensitized to angiotensin II.
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- Johansson, Maria E, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Andersson, Irene J (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Alexanderson, Camilla, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Skøtt, Ole (författare)
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- Holmäng, Agneta, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- American Physiological Society, 2008
- 2008
- Engelska.
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Ingår i: American Journal of Physiology. Regulatory Integrative and Comparative Physiology (USA). - : American Physiological Society. - 0363-6119 .- 0363-6119 .- 1522-1490. ; 294:4
- Relaterad länk:
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http://ajpregu.physi...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The effect of insulin on blood pressure (BP) is debated, and an involvement of an activated renin-angiotensin aldosterone system (RAAS) has been suggested. We studied the effect of chronic insulin infusion on telemetry BP and assessed sympathetic activity and dependence of the RAAS. Female Sprague-Dawley rats received insulin (2 units/day, INS group, n = 12) or insulin combined with losartan (30 mg.kg(-1).day(-1), INS+LOS group, n = 10), the angiotensin II receptor antagonist, for 6 wk. Losartan-treated (LOS group, n = 10) and untreated rats served as controls (n = 11). We used telemetry to measure BP and heart rate (HR), and acute ganglion blockade and air-jet stress to investigate possible control of BP by the sympathetic nervous system. In addition, we used myograph technique to study vascular function ex vivo. The INS and INS+LOS groups developed euglycemic hyperinsulinemia. Insulin did not affect BP but increased HR (27 beats/min on average). Ganglion blockade reduced mean arterial pressure (MAP) similarly in all groups. Air-jet stress did not increase sympathetic reactivity but rather revealed possible blunting of the stress response in hyperinsulinemia. Chronic losartan markedly reduced 24-h-MAP in the INS+LOS group (-38 +/- 1 mmHg P < 0.001) compared with the LOS group (-18 +/- 1 mmHg, P
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Acetylcholine
- pharmacology
- Angiotensin II
- metabolism
- Angiotensin II Type 1 Receptor Blockers
- pharmacology
- Animals
- Antihypertensive Agents
- pharmacology
- therapeutic use
- Aorta
- physiopathology
- Blood Glucose
- metabolism
- Blood Pressure
- drug effects
- Blood Pressure Monitoring
- Ambulatory
- methods
- Disease Models
- Animal
- Female
- Ganglia
- Sympathetic
- drug effects
- physiopathology
- Ganglionic Blockers
- pharmacology
- Glucose
- administration & dosage
- Heart Rate
- drug effects
- Hexamethonium
- pharmacology
- Hyperinsulinism
- chemically induced
- complications
- drug therapy
- metabolism
- physiopathology
- Hypertension
- drug therapy
- etiology
- metabolism
- physiopathology
- Insulin
- administration & dosage
- Insulin Infusion Systems
- Losartan
- pharmacology
- therapeutic use
- Myography
- Rats
- Rats
- Sprague-Dawley
- Renin
- blood
- Renin-Angiotensin System
- drug effects
- genetics
- Telemetry
- Time Factors
- Vasodilation
- Vasodilator Agents
- pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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