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Population pharmaco...
Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.
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- Tärning, Joel, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Ashley, EA (author)
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Lindegardh, Niklas (author)
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Stepniewska, K (author)
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Phaiphun, L (author)
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Day, NP (author)
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McGready, R (author)
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- Ashton, Michael, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Nosten, F (author)
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White, NJ (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Antimicrobial Agents and Chemotherapy. - 0066-4804. ; 52:3, s. 1052-61
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https://doi.org/10.1...
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Abstract
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- The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-piperaquine were characterized. Piperaquine pharmacokinetics in 98 Burmese and Karen patients aged 3 to 55 years were described by a two-compartment disposition model with first-order absorption and interindividual random variability on all parameters and were similar with the three- and four-dose regimens. Children had a lower body weightnormalized oral clearance than adults, resulting in longer terminal elimination half-lives and higher total exposure to piperaquine (area under the concentration-time curve from 0 to 63 days [AUCday 0–63]). However, children had lower plasma concentrations in the therapeutically relevant posttreatment prophylactic period (AUCday 3–20) because of smaller body weight-normalized central volumes of distribution and shorter distribution half-lives. Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- pharmacokinetics malaria
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tärning, Joel, 1 ...
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Ashley, EA
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Lindegardh, Nikl ...
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Stepniewska, K
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Phaiphun, L
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Day, NP
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show more...
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McGready, R
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Ashton, Michael, ...
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Nosten, F
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White, NJ
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Antimicrobial Ag ...
- By the university
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University of Gothenburg