The Healing Process of an Ileostomy to a Percutaneous Titanium Implant: a Short Term Experimental Study on animals

• Introduction: Many diseases such as e.g. ulcerative colitis, colorectal cancer, familial adenomatous polyposis as well as bladder cancer often require surgery with removal of all or part of the intestines or urinary bladder with construction of an abdominal stoma. External stoma appliances or internal ileal pouches have to be used for collection of bowel contents and urine, respectively. It is hypothesized that by attachment of the intestine to a percutaneous implant, a fully continent stoma might be achieved. Such an attachment needs to be instantaneous, permanent and leakage free. As of today there is no implant or structure known to merge with intestine. The principal aim of the present study was to evaluate the tissue response to a newly designed implant. Apart from the healing process of the abdominal tissues to the implant surface, special focus was directed to the adherence of the ileal serosa to the inner surface of the implant. Conclusions: The present results demonstrate convincingly that the serosal side of the intestine may attach and merge with the internal structure of the implant. These studies provide a basis for optimization of the surgical procedure prior to long-term trials.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

Nyckelord

biomaterials

stoma

ileostomy

titanium

percutaneous

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