Autism and epilepsy (and tuberous sclerosis?) in two pre-adolescent boys: neuropsychiatric aspects before and after epilepsy surgery.

• We report on two pre-adolescent boys with a combination of severe seizure disorders and severe-moderate autism who underwent brain surgery for their epilepsy at the ages of 9 and 10 years, respectively. Both boys became seizure-free and initially improved dramatically with regard to autism symptoms. One of the boys continued to improve, but the other had a relapse to his pre-operative state in conjunction with his pubertal growth spurt. Several years after surgery, one of the boys remained much improved with respect to his autism. The other subject showed some improvement with respect to self-injury and aggression, and had slightly lower scores on screens for autism symptoms than in the year preceding epilepsy surgery. The histopathological examination of the brain tissue that was removed at surgery suggested a diagnosis of tuberous sclerosis in both cases.

Nyckelord

Autistic Disorder

complications

diagnosis

Brain

physiopathology

surgery

Child

Epilepsy

complications

physiopathology

surgery

Follow-Up Studies

Humans

Male

Psychiatric Status Rating Scales

Treatment Outcome

Tuberous Sclerosis

complications

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)