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Antiretroviral trea...
Antiretroviral treatment of central nervous system HIV-1 infection: a review
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Hagberg, Lars, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: HIV Med. ; 2:2, s. 97-104
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- HIV-1 infects the central nervous system (CNS) and it has been feared that the CNS may be a sanctuary site where HIV-1 could hide and continue to replicate despite otherwise effective antiretroviral treatment. Neurological HIV-1 related symptoms, cerebrospinal fluid (CSF) viral load, intrathecal immunoactivation and CSF drug concentration measurements are considered in this review of antiretroviral treatment effects on CNS HIV-1 infection. We conclude that antiretroviral combination treatment regimens improve neurocognitive symptoms in HIV-1 infection and substantially lower CSF viral load. The threat of an increasing number of patients with neurological symptoms and continued HIV-1 replication in the brain despite otherwise effective antiretroviral therapy has not yet proved to be a problem. It is, however, important to keep this potential risk in mind, and more longitudinal prospective studies addressing the issue of antiretroviral treatment effects on CNS HIV-1 infection are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Anti-HIV Agents/cerebrospinal fluid/*therapeutic use
- Central Nervous System/*virology
- Central Nervous System Infections/cerebrospinal fluid/*drug
- therapy/virology
- HIV Infections/cerebrospinal fluid/*drug therapy
- HIV-1/*pathogenicity
- Humans
- Viral Load
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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