CD4+ CD25high regulatory T cells reduce T cell transendothelial migration in cancer patients.

• Cell-mediated immunity is thought to be the main mechanism of anti-tumour responses of the host, but it is not known if cancer disease affects T cell recruitment from blood to tissues. Therefore, we compared Heliobacter pylori-induced T cell transendothelial migration (TEM) in H. pylori-infected gastric carcinoma patients, colon and lung carcinoma patients and healthy volunteers. H. pylori induced significant T cell migration from all groups. However, there was a dramatic reduction of T cell TEM in gastric carcinoma patients (80%) compared to healthy individuals. A similarly reduced transmigration was also seen in colon and lung carcinoma patients. We found significantly increased frequencies of T(reg) cells in the blood of gastric carcinoma patients compared to healthy individuals, and depletion of T(reg) cells from the blood of these patients prior to TEM restored T cell migration. The effect of T(reg) cells was largely dependent on cell-cell contact, but not on IL-10 or TGF-beta. In addition, the presence of T(reg) cells led to reduced T cell attachment to endothelium and decreased production of T cell-recruiting chemokines during TEM. In conclusion, T(reg) cell-mediated reduction of T cell TEM may reduce T cell recruitment in patients with epithelial malignancies, thereby hampering anti-tumour responses.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Carcinoma

Non-Small-Cell Lung

immunology

pathology

Cell Adhesion

immunology

Cell Migration Inhibition

Cell Movement

immunology

Colonic Neoplasms

immunology

pathology

Contact Inhibition

immunology

Endothelium

Vascular

cytology

immunology

metabolism

Female

Helicobacter pylori

immunology

Humans

Interleukin-2 Receptor alpha Subunit

biosynthesis

Lung Neoplasms

immunology

pathology

Male

Middle Aged

Stomach Neoplasms

immunology

pathology

T-Lymphocytes

Regulatory

immunology

metabolism

pathology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)