The cellular composition and morphological organization of the rostral migratory stream in the adult human brain.

• The rostral migratory stream (RMS) is the major pathway by which progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb (OB) in rodents, rabbits and primates. However, the existence of an RMS within the adult human brain has been elusive. Immunohistochemical studies utilising cell-type specific markers for early progenitor cells (CD133), proliferating cells (PCNA), astrocytes and type B cells (GFAP) and migrating neuroblasts (PSA-NCAM), reveal that the adult human RMS is organized into layers containing glial cells, proliferating cells and neuroblasts. In addition, the RMS is arranged around a remnant of the ventricular cavity that extends from the SVZ to the OB as seen by immunohistological staining analysis and electron microscopy, showing the presence of basal bodies and a typical 9+2 arrangement of tubulin in tufts of cilia from all levels of the RMS. Overall, these findings suggest that a pathway of migratory progenitor cells similar to that seen in other mammals is present within the adult human brain and that this pathway could provide for neurogenesis in the human forebrain. These findings contribute to the scientific understanding of adult neurogenesis and establish the detailed cytoarchitecture of this novel neurogenic niche in the human brain.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Adult

Animals

Antigens

CD

metabolism

Brain

anatomy & histology

cytology

Cell Movement

physiology

Cerebral Ventricles

cytology

physiology

Cilia

physiology

Coloring Agents

Eosine Yellowish-(YS)

Fluorescent Dyes

Glial Fibrillary Acidic Protein

metabolism

Glycoproteins

metabolism

Hematoxylin

Humans

Image Processing

Computer-Assisted

Immunohistochemistry

Indoles

Male

Microscopy

Electron

Transmission

Neural Cell Adhesion Molecules

metabolism

Neural Pathways

anatomy & histology

cytology

metabolism

Olfactory Bulb

cytology

physiology

Paraffin Embedding

Peptides

metabolism

Proliferating Cell Nuclear Antigen

metabolism

Rats

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)