Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I.

• OBJECTIVE: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). METHODS: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. RESULTS: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated. CONCLUSION: The WINROP algorithm may be a useful tool for modification of ROP screening.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Nyckelord

Algorithms

Biological Markers

blood

Birth Weight

physiology

False Positive Reactions

Female

Gestational Age

Humans

Infant

Infant

Newborn

Infant

Premature

blood

Insulin-Like Growth Factor Binding Protein 3

blood

Insulin-Like Growth Factor I

analysis

Male

Predictive Value of Tests

Prospective Studies

Radioimmunoassay

Reproducibility of Results

Retinopathy of Prematurity

blood

etiology

Risk Factors

Sensitivity and Specificity

Biomarkers/blood

Birth Weight/physiology

Infant, Newborn

Infant, Premature/blood

Insulin-Like Growth Factor Binding Protein 3/blood

Insulin-Like Growth Factor I/analysis

Retinopathy of Prematurity/blood

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)