Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure.

• Leptin is involved in regulating food intake, energy balance and bone formation. Increasing evidence suggests that leptin is also involved in fetal growth and development. The aim of this study was to determine if increased maternal leptin is followed by changes in body composition, skeletal growth or hormonal regulation in the adult rat offspring. Pregnant rats were given injections of either human recombinant leptin (3.5 mg/kg, i.p.) or vehicle on days 8, 10 and 12 of gestation. Both genders of leptin-exposed offspring showed significantly reduced adipose tIssue weight at adult age. Skeletal growth and cortical bone dimensions were significantly reduced. Circulating testosterone levels were significantly increased in female leptin-exposed offspring, and male leptin-exposed offspring had significant testicular enlargement. No significant effects were seen on circulating leptin levels or hypothalamic protein levels of the leptin receptor. The results demonstrate that maternally administered leptin is involved in fetal growth and development, leading to lean offspring with reduced skeletal growth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

Adipose Tissue

growth & development

Animals

Body Composition

drug effects

Body Weight

drug effects

Bone Density

drug effects

Bone Development

Eating

drug effects

Female

Gestational Age

Gonadal Steroid Hormones

blood

Leptin

blood

pharmacology

Male

Pregnancy

Prenatal Exposure Delayed Effects

Rats

Rats

Wistar

Recombinant Proteins

pharmacology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)