Testosterone treatment induces behavioral disinhibition in adult male rats.

• The importance of testosterone for impulsive-like behavior is unclear. Here we studied the effect of testosterone administration during 6 and 14 days (separate experiments) with one, three and five testosterone-filled silastic capsules implanted subcutaneously on shock-induced behavioral inhibition and on flunitrazepam-induced disinhibition in a modified Vogel's drinking conflict model in rats. Alleviation of shock-induced behavioral inhibition has been suggested to reflect impulsive-like behavior and/or anxiolysis. Treatment with the highest testosterone dose used for 6 (Experiment 1) and 14 (Experiment 3) days increased the number of shocks accepted. Testosterone treatment affected serum levels of testosterone and accessory sex organ weights. Flunitrazepam induced behavioral disinhibition in both testosterone-treated (for 14 days) and sham-treated rats. Moreover, testosterone treatment for 14 days resulted in enhanced GABA-induced 36Cl- uptake into synaptoneurosomes as compared to controls. In conclusion, testosterone produces behavioral disinhibition and may enhance brain GABAA receptor function.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Beroendelära (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Substance Abuse (hsv//eng)

Nyckelord

Androgens

pharmacology

Animals

Behavior

Animal

drug effects

Central Nervous System Depressants

pharmacology

Chlorides

metabolism

Dose-Response Relationship

Drug

Drinking

physiology

Drug Implants

Electroshock

Ethanol

pharmacology

Flunitrazepam

pharmacology

GABA Modulators

pharmacology

Genitalia

Male

anatomy & histology

drug effects

Inhibition (Psychology)

Male

Motivation

Organ Size

drug effects

Rats

Rats

Sprague-Dawley

Receptors

GABA-A

drug effects

Synaptosomes

drug effects

metabolism

Testosterone

blood

pharmacology

gamma-Aminobutyric Acid

pharmacology

physiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)