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Consensus paper of ...
Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.
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Wiltfang, J (författare)
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Lewczuk, P (författare)
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Riederer, P (författare)
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Grünblatt, E (författare)
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Hock, C (författare)
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Scheltens, P (författare)
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Hampel, H (författare)
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Vanderstichele, H (författare)
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Iqbal, K (författare)
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Galasko, D (författare)
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- Lannfelt, L (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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Otto, M (författare)
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Esselmann, H (författare)
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Henkel, A W (författare)
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Kornhuber, J (författare)
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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(creator_code:org_t)
- 2009-07-12
- 2005
- Engelska.
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Ingår i: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. - : Informa UK Limited. - 1562-2975. ; 6:2, s. 69-84
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Abstract
Ämnesord
Stäng
- Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, Abeta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.
Nyckelord
- Aged
- Alzheimer Disease
- blood
- cerebrospinal fluid
- genetics
- Amyloid beta-Protein Precursor
- cerebrospinal fluid
- Apolipoproteins E
- genetics
- Biological Markers
- blood
- cerebrospinal fluid
- Consensus
- Diagnosis
- Differential
- Genotype
- Humans
- Immunoblotting
- Microtubule-Associated Proteins
- metabolism
- Neurons
- metabolism
- Phosphorylation
- Spectrometry
- Mass
- Matrix-Assisted Laser Desorption-Ionization
- Time Factors
- tau Proteins
- cerebrospinal fluid
- Aged
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wiltfang, J
-
Lewczuk, P
-
Riederer, P
-
Grünblatt, E
-
Hock, C
-
Scheltens, P
-
visa fler...
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Hampel, H
-
Vanderstichele, ...
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Iqbal, K
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Galasko, D
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Lannfelt, L
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Otto, M
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Esselmann, H
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Henkel, A W
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Kornhuber, J
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Blennow, Kaj, 19 ...
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visa färre...
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The world journa ...
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The World Journa ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet