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3He MRI-based asses...
3He MRI-based assessment of posture-dependent regional ventilation gradients in rats
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- Månsson, Sven (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital,Diagnostisk radiologi, Malmö,Radiology Diagnostics, Malmö
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- Deninger, Anselm J (författare)
- Amersham Health R and D, Malmö
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- Magnusson, Peter (författare)
- Amersham Health R and D, Malmö
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- Pettersson, Göran (författare)
- Amersham Health R and D, Malmö
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- Olsson, Lars E (författare)
- Amersham Health R and D, Malmö
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Hansson, Georg (författare)
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- Wollmer, Per (författare)
- Lund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups,Skåne University Hospital
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- Golman, Klaes (författare)
- Amersham Health R and D, Malmö
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(creator_code:org_t)
- American Physiological Society, 2005
- 2005
- Engelska 9 s.
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Ingår i: Journal of Applied Physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 98:6, s. 67-2259
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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Abstract
Ämnesord
Stäng
- A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He breaths, which allowed for computation of a regional ventilation parameter. A group of six anesthetized rats was studied in both supine and prone postures. Three-dimensional maps of the ventilation parameter were obtained with high spatial resolution (voxel volume approximately 2 mm(3)). Vertical (dorsal-ventral) gradients of the ventilation index, defined as the regional ventilation normalized by the average ventilation within the whole lung, were investigated. Variations in the regional distribution of the ventilation parameter, as well as of the ventilation index, could be detected, depending on the posture of the rats. In supine posture, ventilation was elevated in the dependent parts of the lungs, with a linear gradient of the ventilation index of -0.11 +/- 0.03 cm(-1). In prone posture, the distribution of ventilation was more uniform, with a significantly (P < 0.001) smaller gradient of the ventilation index of -0.01 +/- 0.02 cm(-1). It is concluded that the (3)He MRI-based method can detect and quantify regional ventilation gradients in animals as small as the rat and that these gradients depend on prone or supine posture of the animal.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Administration, Inhalation
- Algorithms
- Animals
- Contrast Media
- Helium
- Image Interpretation, Computer-Assisted
- Imaging, Three-Dimensional
- Isotopes
- Lung
- Magnetic Resonance Imaging
- Men
- Posture
- Prone Position
- Pulmonary Ventilation
- Rats
- Rats, Sprague-Dawley
- Supine Position
- hyperpolarized gas magnetic resonance imaging
- posture dependence
- lung function
- helium-3
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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