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A panel of biomarke...
A panel of biomarkers for diagnosis of prostate cancer using urine samples
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- Guo, Jinan (författare)
- Jinan University
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- Yang, Jianggen (författare)
- Jinan University
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- Zhang, Xuhui (författare)
- Jinan University
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- Feng, Xiaoyan (författare)
- Beijing Institute of Basic Medical Sciences
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- Zhang, Heqiu (författare)
- Beijing Institute of Basic Medical Sciences
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- Chen, Lingwu (författare)
- Sun Yat-sen University
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- Johnson, Heather (författare)
- Olympia Diagnostics Inc.
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- Persson, Jenny L. (författare)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Translational Medicine, Lund University, Malmö, Sweden
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- Xiao, Kefeng (författare)
- Jinan University
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(creator_code:org_t)
- 2018-03-01
- 2018
- Engelska 7 s.
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Ingår i: Anticancer research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 38:3, s. 1471-1477
- Relaterad länk:
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http://dx.doi.org/10...
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http://ar.iiarjourna...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background/Aim: Prostate cancer (PCa) diagnosis using patient urine samples represents a non-invasive and more convenient method than the conventional biopsy and prostate-specific antigen (PSA) test. This study intended to identify a biomarker panel to distinguish PCa from benign prostate using urine samples. Materials and Methods: We identified six biomarkers with differential gene expression in 154 PCa and benign prostate specimens. We then determined mRNA expression signature and the diagnostic performance of the 6-biomarker panel in 156 urine samples from patients with PCa and benign disease. Results: The 6-biomarker panel distinguished PCa from benign prostate cases with sensitivity of 80.6%, specificity of 62.9% and area under the curve (AUC) of 0.803 (p<0.0001), whereas serum PSA at 4 ng/ml cutoff had sensitivity of 95.5%, specificity of 20.2% and AUC of 0.521 (p<0.0001). Conclusion: The 6-biomarker panel for use in urine samples was able to distinguish PCa from benign prostate with higher specificity and accuracy than PSA and may be useful in clinical settings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- Prostate cancer biomarkers
- Prostate cancer diagnosis
- Prostate cancer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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