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Interleukin-1 recep...
Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies
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- Zarezadeh Mehrabadi, Ali (författare)
- Iran University of Medical Sciences
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- Shahba, Faezeh (författare)
- Iran University of Medical Sciences
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- Khorramdelazad, Hossein (författare)
- Rafsanjan University of Medical Sciences
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- Aghamohammadi, Nazanin (författare)
- Iran University of Medical Sciences
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- Karimi, Milad (författare)
- Iran University of Medical Sciences
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- Bagherzadeh, Kowsar (författare)
- Iran University of Medical Sciences
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- Khoshmirsafa, Majid (författare)
- Iran University of Medical Sciences
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- Massoumi, Ramin (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Tumor Pathology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Falak, Reza (författare)
- Iran University of Medical Sciences
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Critical Reviews in Oncology/Hematology. - 1040-8428. ; 193
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cancer immunotherapy
- Chronic inflammation
- IL-1 receptor accessory protein
- Interleukin-1
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