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Animal models of ne...
Animal models of neurological deficits: how relevant is the rat?
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- Cenci Nilsson, Angela (författare)
- Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Basal Ganglia Pathophysiology,Lund University Research Groups
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Whishaw, Ian Q (författare)
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Schallert, Timothy (författare)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2002
- 2002
- Engelska.
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Ingår i: Nature Reviews Neuroscience. - : Springer Science and Business Media LLC. - 1471-003X .- 1471-0048. ; 3:7, s. 574-579
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Animal models of neurological deficits are essential for the assessment of new therapeutic options. It has been suggested that rats are not as appropriate as primates for the symptomatic modelling of disease, but a large body of data argues against this view. Comparative analyses of movements in rats and primates show homology of many motor patterns across species. Advances have been made in identifying rat equivalents of akinesia, tremor, postural deficits and dyskinesia, which are relevant to Parkinson's disease. Rat models of hemiplegia, neglect and tactile extinction are useful in assessing the outcome of ischaemic or traumatic brain injury, and in monitoring the effects of therapeutic interventions. Studies in rodents that emphasize careful behavioural analysis should continue to be developed as effective and inexpensive models that complement studies in primates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Efferent Pathways : physiopathology
- Dyskinesias : physiopathology
- Animal
- Brain Ischemia : physiopathology
- Brain Injuries : physiopathology
- Disease Models
- Human
- Nervous System Diseases : physiopathology
- Parkinson Disease : physiopathology
- Primates
- Rats
- Reproducibility of Results
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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