Sökning: id:"swepub:oai:lup.lub.lu.se:02c0a1ff-1f79-46f4-b4d7-6ffff45155f9" >
In situ pneumococca...
In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector
-
- Li, Yi (författare)
- The State University of New York
-
- Beitelshees, Marie (författare)
- The State University of New York
-
- Fang, Lei (författare)
- The State University of New York
-
visa fler...
-
- Hill, Andrew (författare)
- Abcombi Biosciences Inc.
-
- Ahmadi, Mahmoud Kamal (författare)
- The State University of New York
-
- Chen, Mingfu (författare)
- The State University of New York
-
- Davidson, Bruce A (författare)
- The State University of New York
-
- Knight, Paul (författare)
- The State University of New York
-
- Smith, Randall J (författare)
- The State University of New York
-
- Andreadis, Stelios T (författare)
- The State University of New York
-
- Hakansson, Anders P (författare)
- Lund University,Lunds universitet,Experimentell infektionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Experimental Infection Medicine, Malmö,Lund University Research Groups,The State University of New York
-
- Jones, Charles H (författare)
- The State University of New York
-
- Pfeifer, Blaine A (författare)
- The State University of New York
-
visa färre...
-
The State University of New York Abcombi Biosciences Inc (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2016
- 2016
- Engelska.
-
Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 2:7
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://advances.sci...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The type and potency of an immune response provoked during vaccination will determine ultimate success in disease prevention. The basis for this response will be the design and implementation of antigen presentation to the immune system. Whereas direct antigen administration will elicit some form of immunological response, a more sophisticated approach would couple the antigen of interest to a vector capable of broad delivery formats and designed for heightened response. New antigens associated with pneumococcal disease virulence were used to test the delivery and adjuvant capabilities of a hybrid biological-biomaterial vector consisting of a bacterial core electrostatically coated with a cationic polymer. The hybrid design provides (i) passive and active targeting of antigen-presenting cells, (ii) natural and multicomponent adjuvant properties, (iii) dual intracellular delivery mechanisms, and (iv) a simple formulation mechanism. In addition, the hybrid format enables device-specific, or in situ, antigen production and consolidation via localization within the bacterial component of the vector. This capability eliminates the need for dedicated antigen production and purification before vaccination efforts while leveraging the aforementioned features of the overall delivery device. We present the first disease-specific utilization of the vector toward pneumococcal disease highlighted by improved immune responses and protective capabilities when tested against traditional vaccine formulations and a range of clinically relevant Streptococcus pneumoniae strains. More broadly, the results point to similar levels of success with other diseases that would benefit from the production, delivery, and efficacy capabilities offered by the hybrid vector.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Journal Article
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Li, Yi
-
Beitelshees, Mar ...
-
Fang, Lei
-
Hill, Andrew
-
Ahmadi, Mahmoud ...
-
Chen, Mingfu
-
visa fler...
-
Davidson, Bruce ...
-
Knight, Paul
-
Smith, Randall J
-
Andreadis, Steli ...
-
Hakansson, Ander ...
-
Jones, Charles H
-
Pfeifer, Blaine ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Science Advances
- Av lärosätet
-
Lunds universitet