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Household compositi...
Household composition and the infant fecal microbiome : The INSPIRE study
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- Lane, Avery A. (författare)
- Washington State University
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- McGuire, Michelle K. (författare)
- University of Idaho
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- McGuire, Mark A. (författare)
- University of Idaho
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visa fler...
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- Williams, Janet E. (författare)
- University of Idaho
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- Lackey, Kimberly A. (författare)
- University of Idaho
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- Hagen, Edward H. (författare)
- Washington State University
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- Kaul, Abhishek (författare)
- Washington State University
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- Gindola, Debela (författare)
- Hawassa University
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- Gebeyehu, Dubale (författare)
- Hawassa University
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- Flores, Katherine E. (författare)
- Washington State University
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- Foster, James A. (författare)
- University of Idaho
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- Sellen, Daniel W. (författare)
- University of Toronto
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- Kamau-Mbuthia, Elizabeth W. (författare)
- Egerton University
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- Kamundia, Egidioh W. (författare)
- Egerton University
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- Mbugua, Samwel (författare)
- Egerton University
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- Moore, Sophie E. (författare)
- King's College London,Medical Research Council Laboratories Gambia
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- Prentice, Andrew M. (författare)
- London School of Hygiene and Tropical Medicine,Medical Research Council Laboratories Gambia
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- Kvist, Linda J. (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups
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- Otoo, Gloria E. (författare)
- University of Ghana
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- Rodríguez, Juan M. (författare)
- Complutense University of Madrid
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- Ruiz, Lorena (författare)
- Complutense University of Madrid,CSIC Instituto de Productos Lácteos de Asturias (IPLA)
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- Pareja, Rossina G. (författare)
- Instituto de Investigacion Nutricional Lima
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- Bode, Lars (författare)
- University of California, San Diego
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- Price, William J. (författare)
- University of Idaho
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- Meehan, Courtney L. (författare)
- Washington State University
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visa färre...
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(creator_code:org_t)
- 2019-04-22
- 2019
- Engelska.
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Ingår i: American Journal of Physical Anthropology. - : Wiley. - 0002-9483 .- 1096-8644. ; 3:169, s. 526-539
- Relaterad länk:
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http://dx.doi.org/10...
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https://rss.onlineli...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Establishment and development of the infant gastrointestinal microbiome (GIM) varies cross-culturally and is thought to be influenced by factors such as gestational age, birth mode, diet, and antibiotic exposure. However, there is little data as to how the composition of infants' households may play a role, particularly from a cross-cultural perspective. Here, we examined relationships between infant fecal microbiome (IFM) diversity/composition and infants' household size, number of siblings, and number of other household members. Materials and methods: We analyzed 377 fecal samples from healthy, breastfeeding infants across 11 sites in eight different countries (Ethiopia, The Gambia, Ghana, Kenya, Peru, Spain, Sweden, and the United States). Fecal microbial community structure was determined by amplifying, sequencing, and classifying (to the genus level) the V1–V3 region of the bacterial 16S rRNA gene. Surveys administered to infants' mothers identified household members and composition. Results: Our results indicated that household composition (represented by the number of cohabitating siblings and other household members) did not have a measurable impact on the bacterial diversity, evenness, or richness of the IFM. However, we observed that variation in household composition categories did correspond to differential relative abundances of specific taxa, namely: Lactobacillus, Clostridium, Enterobacter, and Klebsiella. Discussion: This study, to our knowledge, is the largest cross-cultural study to date examining the association between household composition and the IFM. Our results indicate that the social environment of infants (represented here by the proxy of household composition) may influence the bacterial composition of the infant GIM, although the mechanism is unknown. A higher number and diversity of cohabitants and potential caregivers may facilitate social transmission of beneficial bacteria to the infant gastrointestinal tract, by way of shared environment or through direct physical and social contact between the maternal–infant dyad and other household members. These findings contribute to the discussion concerning ways by which infants are influenced by their social environments and add further dimensionality to the ongoing exploration of social transmission of gut microbiota and the “old friends” hypothesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- gastrointestinal
- horizontal transmission
- microbiota
- siblings
- social transmission
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lane, Avery A.
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McGuire, Michell ...
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McGuire, Mark A.
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Williams, Janet ...
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Lackey, Kimberly ...
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Hagen, Edward H.
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visa fler...
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Kaul, Abhishek
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Gindola, Debela
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Gebeyehu, Dubale
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Flores, Katherin ...
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Foster, James A.
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Sellen, Daniel W ...
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Kamau-Mbuthia, E ...
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Kamundia, Egidio ...
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Mbugua, Samwel
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Moore, Sophie E.
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Prentice, Andrew ...
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Kvist, Linda J.
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Otoo, Gloria E.
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Rodríguez, Juan ...
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Ruiz, Lorena
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Pareja, Rossina ...
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Bode, Lars
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Price, William J ...
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Meehan, Courtney ...
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visa färre...
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