Childhood malignancy and maternal diabetes or other auto-immune disease during pregnancy.

• Among 4380 children born in 1987-1997 of women with a diagnosis of diabetes and alive at the age of one, 10 were registered in the Swedish Cancer Registry before the end of 1998. The odds ratio for having a childhood cancer after maternal diabetes, stratified for year of birth, maternal age, parity, multiple birth, and 500 g birth weight class was 2.25 (95%CI 1.22-4.15). Among 5842 children born during the period 1973-1997 whose mothers had other auto-immune diseases (SLE, rheumatoid arthritis, Crohn, ulcerous colitis, multiple sclerosis or thyroiditis), the number of observed childhood cancers (9) was close to that expected (8.5). Maternal diabetes but not other auto-immune diseases may be a risk factor for childhood cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Child Welfare

Child

Preschool

Diabetes Mellitus

Insulin-Dependent : complications

Female

Infant

Human

Newborn

Male

Neoplasms : etiology

Pregnancy

Prenatal Exposure Delayed Effects

Autoimmune Diseases : complications

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)