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Very long-term surv...
Very long-term survival and late sudden cardiac death in cardiac resynchronization therapy patients
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- Barra, Sérgio (författare)
- Papworth Hospital
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- Duehmke, Rudolf (författare)
- West Suffolk Hospital
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- Providência, Rui (författare)
- National Health Service Trust, NHS England
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- Narayanan, Kumar (författare)
- Paris Cardiovascular Research Center (PARCC)
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- Reitan, Christian (författare)
- Lund University,Lunds universitet,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Roubicek, Tomas (författare)
- Regional Hospital Liberec
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- Polasek, Rostislav (författare)
- Regional Hospital Liberec
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- Chow, Antony (författare)
- National Health Service Trust, NHS England
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- Defaye, Pascal (författare)
- Grenoble University Hospital
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- Fauchier, Laurent (författare)
- University Of Tours
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- Piot, Olivier (författare)
- Centre Cardiologique du Nord, Saint Denis
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- Deharo, Jean-Claude (författare)
- La Timone University Hospital
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- Sadoul, Nicolas (författare)
- University Hospital of Nancy
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- Klug, Didier (författare)
- University of Lille,Lille University Hospital
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- Garcia, Rodrigue (författare)
- Poitiers University Hospital
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- Dockrill, Seth (författare)
- Papworth Hospital
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- Virdee, Munmohan (författare)
- Papworth Hospital
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- Pettit, Stephen (författare)
- Papworth Hospital
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- Agarwal, Sharad (författare)
- Papworth Hospital
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- Borgquist, Rasmus (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Electrocardiology Research Group - CIEL,Clinical studies af Atrial Fibrillation,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Marijon, Eloi (författare)
- Paris Descartes University
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- Boveda, Serge (författare)
- Clinique Pasteur, Toulouse
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(creator_code:org_t)
- 2019-05-02
- 2019
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 40:26, s. 2121-2127
- Relaterad länk:
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http://dx.doi.org/10...
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https://discovery.uc...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AIMS: The very long-term outcome of patients who survive the first few years after receiving cardiac resynchronization therapy (CRT) has not been well described thus far. We aimed to provide long-term outcomes, especially with regard to the occurrence of sudden cardiac death (SCD), in CRT patients without (CRT-P) and with defibrillator (CRT-D).METHODS AND RESULTS: A total of 1775 patients, with ischaemic or non-ischaemic dilated cardiomyopathy, who were alive 5 years after CRT implantation, were enrolled in this multicentre European observational cohort study. Overall long-term mortality rates and specific causes of death were assessed, with a focus on late SCD. Over a mean follow-up of 30 months (interquartile range 10-42 months) beyond the first 5 years, we observed 473 deaths. The annual age-standardized mortality rates of CRT-D and CRT-P patients were 40.4 [95% confidence interval (CI) 35.3-45.5] and 97.2 (95% CI 85.5-109.9) per 1000 patient-years, respectively. The adjusted hazard ratio (HR) for all-cause mortality was 0.99 (95% CI 0.79-1.22). Twenty-nine patients in total died of late SCD (14 with CRT-P, 15 with CRT-D), corresponding to 6.1% of all causes of death in both device groups. Specific annual SCD rates were 8.5 and 5.8 per 1000 patient-years in CRT-P and CRT-D patients, respectively, with no significant difference between groups (adjusted HR 1.0, 95% CI 0.45-2.44). Death due to progressive heart failure represented the principal cause of death (42.8% in CRT-P patients and 52.6% among CRT-D recipients), whereas approximately one-third of deaths in both device groups were due to non-cardiovascular death.CONCLUSION: In this first description of very long-term outcomes among CRT recipients, progressive heart failure death still represented the most frequent cause of death in patients surviving the first 5 years after CRT implant. In contrast, SCD represents a very low proportion of late mortality irrespective of the presence of a defibrillator.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Barra, Sérgio
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Duehmke, Rudolf
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Providência, Rui
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Narayanan, Kumar
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Reitan, Christia ...
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Roubicek, Tomas
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visa fler...
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Polasek, Rostisl ...
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Chow, Antony
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Defaye, Pascal
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Fauchier, Lauren ...
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Piot, Olivier
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Deharo, Jean-Cla ...
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Sadoul, Nicolas
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Klug, Didier
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Garcia, Rodrigue
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Dockrill, Seth
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Virdee, Munmohan
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Pettit, Stephen
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Agarwal, Sharad
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Borgquist, Rasmu ...
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Marijon, Eloi
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Boveda, Serge
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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European Heart J ...
- Av lärosätet
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Lunds universitet