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Association between...
Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8
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- Sanjeevi, C. B. (författare)
- Karolinska Institutet
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- Hagopian, W. A. (författare)
- University of Washington
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- Landin-Olsson, M. (författare)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Skåne University Hospital
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- Kockum, I. (författare)
- Karolinska Institutet
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- Woo, W. (författare)
- University of Washington
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- Palmer, J. P. (författare)
- Veterans Health Administration
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- Lernmark, Å (författare)
- University of Washington,Karolinska University Hospital
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- Dahlquist, G. (författare)
- Umeå University
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(creator_code:org_t)
- 2008-09-30
- 1998
- Engelska.
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Ingår i: Tissue Antigens. - : Wiley. - 0001-2815 .- 1399-0039. ; 51:3, s. 281-286
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and DRB1(*)0401. GAD65 autoantibodies, known to be closely associated with DQA1(*)0501-DQB1(*)0201 (DQ2)-DRB1(*)0301 haplotype, also showed no preferential association with DQA1(*)0301-DQB1(*)0302 (DQ8) versus DRB1(*)04. These results suggest that the immune response to different β-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- DQ
- GAD65 autoantibodies
- HLA-DR
- ICA
- ICA512 autoantibodies
- IDDM
- Insulin autoantibodies
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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